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Stability : Once reconstituted, peptides last 28 days

All participants received a lifestyle intervention involving regular counselling regarding diet and physical activity

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This aligns with findings in human induced pluripotent stem cell-derived sensory neurons (iPSC-SNs), where retigabine and the specific Kv7.2/3 activator ICA-110381 hyperpolarized the resting membrane potential, increased action potential threshold, and robustly inhibited neuronal firing, whereas the Kv7.1-specific activator ML277 had no effect, confirming the critical role of Kv7.2/3 subunits in regulating human sensory neuron excitability (Estacion et al., 2023)